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Article

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.

Cell - 18 Jun 2015

Dosenovic Pia, von Boehmer Lotta, Escolano Amelia, Jardine Joseph, Freund Natalia T, Gitlin Alexander D, McGuire Andrew T, Kulp Daniel W, Oliveira Thiago, Scharf Louise, Pietzsch John, Gray Matthew D, Cupo Albert, van Gils Marit J, Yao Kai-Hui, Liu Cassie, Gazumyan Anna, Seaman Michael S, Björkman Pamela J, Sanders Rogier W, Moore John P, Stamatatos Leonidas, Schief William R, Nussenzweig Michel C

Abstract excerpt

A subset of individuals infected with HIV-1 develops broadly neutralizing antibodies (bNAbs) that can prevent infection, but it has not yet been possible to elicit these antibodies by immunization. To systematically explore how immunization might be tailored to produce them, we generated mice exp...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Viral

Share to CD4 Antigens

Share to env Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 26091035
DOI: 10.1016/j.cell.2015.06.003
PMCID: PMC4604566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26091035-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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