Article
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states.
Nature cancer - 1 Feb 2025
Panzeri Ilaria, Fagnocchi Luca, Apostle Stefanos, Tompkins Megan, Wolfrum Emily, Madaj Zachary, Hostetter Galen, Liu Yanqing, Schaefer Kristen, Yang Chih-Hsiang, Bergsma Alexis, Drougard Anne, Dror Erez, Chandler Darrell P, Schramek Daniel, Triche Timothy J, Pospisilik John Andrew
Abstract excerpt
Mutations in cancer risk genes increase susceptibility, but not all carriers develop cancer. Indeed, while DNA mutations are necessary drivers of cancer, only a small subset of mutated cells go on to cause the disease. To date, the mechanisms underlying individual cancer susceptibility remain unclear. Here, we took advantage of a unique mouse model of intrinsic developmental heterogeneity (Trim28+/D9) to...
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