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Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.

Cell systems - 25 Jan 2017

Winter Jean M, Gildea Derek E, Andreas Jonathan P, Gatti Daniel M, Williams Kendra A, Lee Minnkyong, Hu Ying, Zhang Suiyuan, Mullikin James C, Wolfsberg Tyra G, McDonnell Shannon K, Fogarty Zachary C, Larson Melissa C, French Amy J, Schaid Daniel J, Thibodeau Stephen N, Churchill Gary A, Crawford Nigel P S

Abstract excerpt

It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Integration of disease phenotype and SNP variation data in 493 F1 males identified a metastasis modifier locus on...

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Identifiers

PMID: 27916600
DOI: 10.1016/j.cels.2016.10.018
PMCID: PMC5269474

Genes

CENPU
RWDD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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