Article

Developmental priming of cancer susceptibility

2023-09-15

Abstract excerpt

<h4>SUMMARY</h4> DNA mutations are necessary drivers of cancer, yet only a small subset of mutated cells go on to cause the disease. To date, the mechanisms that determine which rare subset of cells transform and initiate tumorigenesis remain unclear. Here, we take advantage of a unique model of intrinsic developmental heterogeneity ( Trim28 +/D9 ) and demonstrate that stochastic early life epigenetic variation...

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Literature Corpus work: 151ef48a-2561-55a8-ae2b-e433922bab48
DOI: 10.1101/2023.09.12.557446

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