Article
Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
Blood advances - 14 Feb 2023
Muranyi Andrew, Ammer Tobias, Kechter Anna, Rawat Vijay P S, Sinha Amit, Gonzalez-Menendez Irene, Quintanilla-Martinez Leticia, Azoitei Anca, Günes Cagatay, Mupo Annalisa, Vassiliou George, Bamezai Shiva, Buske Christian
Abstract excerpt
NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML). Mutations in the NPM1 gene result in the increased export of NPM1 to the cytoplasm (NPM1c) and are associated with multiple transforming events including the aberrant upregulation of MEIS1 that maintains stem cell and cell cycle-associated pathways in NPM1c AML. However, another consequence of the NPM1c mutation is the inadequate...
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