Article
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Blood - 25 Apr 2013
Sportoletti Paolo, Varasano Emanuela, Rossi Roberta, Bereshchenko Oxana, Cecchini Debora, Gionfriddo Ilaria, Bolli Niccolò, Tiacci Enrico, Intermesoli Tamara, Zanghì Pamela, Masciulli Arianna, Martelli Maria Paola, Falzetti Franca, Martelli Massimo F, Falini Brunangelo
Abstract excerpt
The NPM1 mutation is the most frequent genetic alteration thus far identified in acute myeloid leukemia (AML). Despite progress in the clinical and biological characterization of NPM1-mutated AML, the role of NPM1 mutation in leukemogenesis in vivo has not been fully elucidated. We report a novel mouse model that conditionally expresses the most common human NPM1 mutation (type A) in the hematopoietic...
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