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Article

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.

Oncotarget - 25 Oct 2016

Poitras Jennifer L, Heiser Diane, Li Li, Nguyen Bao, Nagai Kozo, Duffield Amy S, Gamper Christopher, Small Donald

Abstract excerpt

Internal tandem duplications of the juxtamembrane domain of FLT3 (FLT3/ITD) are among the most common mutations in Acute Myeloid Leukemia (AML). Resulting in constitutive activation of the kinase, FLT3/ITD portends a particularly poor prognosis, with reduced overall survival and increased rates of relapse. We previously generated a knock-in mouse, harboring an internal tandem duplication at the endogenous Flt3...

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Share to Leukemia, Myeloid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to fms-Like Tyrosine Kinase 3

Share to Myeloproliferative Disorders

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Tandem Repeat Sequences

Source

Open in PubMed Open full text

Identifiers

PMID: 27636998
DOI: 10.18632/oncotarget.11986
PMCID: PMC5342464

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.PMID 27636998Read ↗

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.Semantic proximity Read ↗

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.Semantic proximity Read ↗

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DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.Semantic proximity Read ↗

Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.Semantic proximity Read ↗

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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformationSemantic proximity Read ↗

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