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Article

Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer

12 Dec 2018

Abstract excerpt

Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). This revealed that the immune microenvironment has high spatial heterogeneity such that intratumoral regional variation is as large as inter-personal variation. While...

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PMID: 30560866
DOI: 10.1038/s41467-018-07767-w

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