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Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

2020-07-02

Abstract excerpt

Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy. Here, we revealed a rather homogeneous mutational landscape but extremely suppressed and heterogeneous T cell receptor (TCR) repertoire in SCLCs. Higher mutational burden, lower chromosomal copy number aberration (CNA) burden, less CNA I...

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Literature Corpus work
7691c68a-a430-57fc-818e-6aa0bdcc4f5f
DOI
10.1101/2020.06.30.180844
Open publication

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Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on SurvivalDOI 10.1101/2020.06.30.180844
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