Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer.

doi:10.1038/s41467-021-26821-8

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Article

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer.

Nature communications - 17 Nov 2021

Chen Ming, Chen Runzhe, Jin Ying, Li Jun, Hu Xin, Zhang Jiexin, Fujimoto Junya, Hubert Shawna M, Gay Carl M, Zhu Bo, Tian Yanhua, McGranahan Nicholas, Lee Won-Chul, George Julie, Hu Xiao, Chen Yamei, Wu Meijuan, Behrens Carmen, Chow Chi-Wan, Pham Hoa H N, Fukuoka Junya, Wu Jia, Parra Edwin Roger, Little Latasha D, Gumbs Curtis, Song Xingzhi, Wu Chang-Jiun, Diao Lixia, Wang Qi, Cardnell Robert, Zhang Jianhua, Wang Jing, Le Xiuning, Gibbons Don L, Heymach John V, Jack Lee J, William William N, Cheng Chao, Glisson Bonnie, Wistuba Ignacio, Andrew Futreal P, Thomas Roman K, Reuben Alexandre, Byers Lauren A, Zhang Jianjun

Abstract excerpt

Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy. Here, using multi-region whole exome/T cell receptor (TCR) sequencing as well as immunohistochemistry, we reveal a rather homogeneous mutational landscape but extremely cold and heterogeneous TCR repertoire in limited-stage SCLC tumors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34789716
DOI: 10.1038/s41467-021-26821-8
PMCID: PMC8599854

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