Article

TCR clonality and TCR clonal expansion in the <i>in situ</i> microenvironment of non-small cell lung cancer

2025-01-04

Abstract excerpt

<h4>Summary</h4> T-cell activation and clonal expansion are essential for the efficacy of immunotherapy in non-small cell lung cancer (NSCLC) patients. Since the distribution of T-cell clones might provide insights into immunogenic mechanisms, we determined the α/β TCR clonality using RNA-sequencing from frozen tumor tissue of 182 NSCLC patients and paired the results with extensive in situ image and sequence an...

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Literature Corpus work: 83dad006-1331-5923-9233-c4e997e169a0
DOI: 10.1101/2024.12.17.628857

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