Article
TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.
Cancer discovery - 1 Oct 2017
Reuben Alexandre, Gittelman Rachel, Gao Jianjun, Zhang Jiexin, Yusko Erik C, Wu Chang-Jiun, Emerson Ryan, Zhang Jianhua, Tipton Christopher, Li Jun, Quek Kelly, Gopalakrishnan Vancheswaran, Chen Runzhe, Vence Luis M, Cascone Tina, Vignali Marissa, Fujimoto Junya, Rodriguez-Canales Jaime, Parra Edwin R, Little Latasha D, Gumbs Curtis, Forget Marie-Andrée, Federico Lorenzo, Haymaker Cara, Behrens Carmen, Benzeno Sharon, Bernatchez Chantale, Sepesi Boris, Gibbons Don L, Wargo Jennifer A, William William N, Swisher Stephen, Heymach John V, Robins Harlan, Lee J Jack, Sharma Padmanee, Allison James P, Futreal P Andrew, Wistuba Ignacio I, Zhang Jianjun
Abstract excerpt
Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens, were shown to alter tumor immunogenicity through T-cell responses. Here, we performed sequencing of the T-cell receptor (TCR) in 45 tumor regions from 11 localized lung adenocarcinomas and observed substantial intratumor differences in T-cell...
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