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Article

Mutation-Driven Immune Microenvironments in Non-Small Cell Lung Cancer: Unrevealing Patterns through Cluster Analysis.

Yonsei medical journal - 1 Dec 2024

Kim Youngtaek, Hwang Joon Yeon, Na Kwangmin, Kim Dong Kwon, Lee Seul, Kang Seong-San, Baek Sujeong, Yang Seung Min, Kim Mi Hyun, Han Heekyung, Jeong Seong Su, Lee Chai Young, Han Yu Jin, Sohn Jie-Ohn, Ye Sang-Kyu, Pyo Kyoung-Ho

Abstract excerpt

PURPOSE: We aimed to comprehensively analyze the immune cell and stromal components of tumor microenvironment at the single-cell level and identify tumor heterogeneity among the major top-derived oncogene mutations in non-small cell lung cancer (NSCLC) using single-cell RNA sequencing (scRNA-seq) data. MATERIALS AND METHODS: The scRNA-seq dataset utilized in this study comprised 64369 primary tumor tissue cells...

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Identifiers

PMID: 39609084
DOI: 10.3349/ymj.2024.0062
PMCID: PMC11605048

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