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Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

2021-01-22

Abstract excerpt

<title>Abstract</title> <p>Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy. Here, using multi-region whole exome/T cell receptor (TCR) sequencing as well as immunohistochemistry (IHC), we revealed a rather homogeneous mutational landscape but extremely cold and heterogeneous TCR reper...

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Literature Corpus work
b5821cce-ace8-563a-8cf4-adc11be971a7
DOI
10.21203/rs.3.rs-148314/v1
Open publication

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