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Experimental and spontaneous metastasis assays can result in divergence in clonal architecture

7 Aug 2023

Abstract excerpt

Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gold standard. Injections of cancer cells in orthotopic sites (spontaneous metastasis assays) or into the vasculature (experimental metastasis assays) have been used...

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PMID: 37550477
DOI: 10.1038/s42003-023-05167-5

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