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Article

Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies.

Genome medicine - 28 Oct 2021

Huang Xiaomeng, Qiao Yi, Brady Samuel W, Factor Rachel E, Downs-Kelly Erinn, Farrell Andrew, McQuerry Jasmine A, Shrestha Gajendra, Jenkins David, Johnson W Evan, Cohen Adam L, Bild Andrea H, Marth Gabor T

Abstract excerpt

BACKGROUND: Metastatic breast cancer is a deadly disease with a low 5-year survival rate. Tracking metastatic spread in living patients is difficult and thus poorly understood. METHODS: Via rapid autopsy, we have collected 30 tumor samples over 3 timepoints and across 8 organs from a triple-negative metastatic breast cancer patient. The large number of sites sampled, together with deep whole-genome sequencing and...

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Identifiers

PMID: 34711268
DOI: 10.1186/s13073-021-00989-6
PMCID: PMC8555066

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Source receipt: pubmed, retrieved 7 Sept 2026.

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