Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

7 Jul 2021

Abstract excerpt

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in this process remains unclear. Here, we optimized the use of optical barcoding to visualize and characterize 31 cancer subclones in vivo. By mapping the clonal composition of thousands of metastases in two clinically relevant sites, the lungs and liver, we found that metastases were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34233875
DOI: 10.1126/sciadv.abf4408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profilePMID 34233875Read ↗

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancerSemantic proximity Read ↗

The breast cancer pro-metastatic phenotype requires concomitant hyper-activation of ECM remodeling and dsRNA-IFN1 signaling in rare clone cellsSemantic proximity Read ↗

Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity Read ↗

Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies.Semantic proximity Read ↗

Novel temporal and spatial patterns of metastatic colonization from rapid-autopsy tumor biopsiesSemantic proximity Read ↗

Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes.Semantic proximity Read ↗

Single‐cell RNA sequencing elucidated the landscape of breast cancer brain metastases and identified ILF2 as a potential therapeutic targetSemantic proximity Read ↗

Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies and their ability to capture intra-tumoral heterogeneitySemantic proximity Read ↗

Beyond Genetics: Metastasis as an Adaptive Response in Breast CancerSemantic proximity Read ↗

A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast CancerSemantic proximity Read ↗

Mutational profiles of breast cancer metastases from a rapid autopsy series reveal multiple evolutionary trajectories.Semantic proximity Read ↗

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.