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Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters

1 Jun 2025

Abstract excerpt

Circulating tumor cell (CTC) clusters are highly efficient metastatic seeds in various cancers. Yet, their genetic heterogeneity and clonal architecture is poorly characterized. Using whole-exome sequencing coupled with phylogenetic inference from CTC clusters of patients with breast and prostate cancer, as well as mouse cancer models alongside barcode-mediated clonal tracking in vivo, we demonstrate oligoclonal...

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PMID: 40457073
DOI: 10.1038/s41588-025-02205-2

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