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Genomewide copy number alteration screening of circulating plasma DNA: potential for the detection of incipient tumors

26 Oct 2018

Abstract excerpt

Background: Early cancer diagnosis might improve survival rates. As circulating tumor DNA (ctDNA) carries cancer-specific modifications, it has great potential as a noninvasive biomarker for detection of incipient tumors. Patients and methods: We collected cell-free DNA (cfDNA) samples of 1002 elderly without a prior malignancy, carried out whole-genome massive parallel sequencing and scrutinized the mapped...

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PMID: 30371735
DOI: 10.1093/annonc/mdy476

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