Article

Genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals

2025-03-06

Abstract excerpt

Mosaic chromosomal alterations of the autosomes (aut-mCAs) are large structural somatic mutations which cause clonal hematopoiesis and increase cancer risk. Here, we detected aut-mCAs in 1,011,269 participants across four biobanks. Through integrative analysis of the minimum critical region and inherited genetic variation, we found that proto-oncogenes exclusively drive chromosomal gains, tumor suppressors drive l...

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Literature Corpus work: 893b9b1a-e12d-5053-a4e2-c4d1f977d6e8
DOI: 10.1101/2025.03.05.25323443

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