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Biological background of the genomic variations of cf-DNA in healthy individuals

22 Nov 2018

Abstract excerpt

BACKGROUND: Cell-free DNA (cf-DNA)-based liquid biopsy is emerging as a revolutionary new method in individualized cancer treatment and prognosis monitoring, although detecting early-stage cancers using cf-DNA remains challenging, partially because of the undefined biological background of cf-DNA. MATERIALS AND METHODS: We investigated somatic mutations in the cf-DNA of 259 cancer-free individuals with a median...

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PMID: 30475948
DOI: 10.1093/annonc/mdy513

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