Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes.

Cell reports. Medicine - 18 Mar 2025

Buttigieg Marco M, Vlasschaert Caitlyn, Bick Alexander G, Vanner Robert J, Rauh Michael J

Abstract excerpt

Clonal hematopoiesis (CH)-the expansion of somatically mutated hematopoietic cells-is common in solid cancers. CH is associated with systemic inflammation, but its impact on tumor biology is underexplored. Here, we report the effects of CH on the tumor microenvironment (TME) using 1,550 treatment-naive patient samples from the Clinical Proteomics Tumor Analysis Consortium (CPTAC) cohort. CH is present in 18.3% of...

Read the complete abstract on PubMed

Topics

Humans
Tumor Microenvironment
Clonal Hematopoiesis
Inflammation
Neoplasms
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 40037357
DOI: 10.1016/j.xcrm.2025.101989
PMCID: PMC11970403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes.PMID 40037357Read ↗

Inflammatory reprogramming of the tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes in solid cancerSemantic proximity Read ↗

The interplay of clonal hematopoiesis and cancer: Clinical implications in oncology.Semantic proximity Read ↗

Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface.Semantic proximity Read ↗

What's hidden in plain sight? Impact of clonal hematopoiesis on the risk and progression of nonhematologic cancers.Semantic proximity Read ↗

Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications.Semantic proximity Read ↗

Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.Semantic proximity Read ↗

Factors associated with clonal hematopoiesis and interaction with marrow environment.Semantic proximity Read ↗

Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated Immune Cells by Clonal Hematopoiesis in the Diseased Tissue.Semantic proximity Read ↗

Tumor-Infiltrating Clonal Hematopoiesis and Pan-Cancer Prognosis in Patients With Solid Tumors.Semantic proximity Read ↗

Clonal Hematopoiesis and Solid CancersSemantic proximity Read ↗

CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors.Semantic proximity Read ↗

CHIP ahoy: charting a decade of discovery in clonal hematopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.