Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

28 Nov 2012

Abstract excerpt

Clinical management of cancer patients could be improved through the development of noninvasive approaches for the detection of incipient, residual, and recurrent tumors. We describe an approach to directly identify tumor-derived chromosomal alterations through analysis of circulating cell-free DNA from cancer patients. Whole-genome analyses of DNA from the plasma of 10 colorectal and breast cancer patients and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23197571
DOI: 10.1126/scitranslmed.3004742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome SequencingPMID 23197571Read ↗

Direct detection of early-stage cancers using circulating tumor DNA.Semantic proximity Read ↗

Identification and Use of Personalized Genomic Markers for Monitoring Circulating Tumor DNA.Semantic proximity Read ↗

Genetic profiling of cancer with circulating tumor DNA analysis.Semantic proximity Read ↗

Testing for oncogenic molecular aberrations in cell-free DNA-based liquid biopsies in the clinic: are we there yet?Semantic proximity Read ↗

Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.Semantic proximity Read ↗

Circulating Cell-Free DNA—Diagnostic and Prognostic Applications in Personalized Cancer TherapySemantic proximity Read ↗

Clinical whole‐genome sequencing in cancer diagnosisSemantic proximity Read ↗

Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNASemantic proximity Read ↗

Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumorsSemantic proximity Read ↗

Sensitive detection of copy number alterations in samples with low circulating tumor DNA fractionSemantic proximity Read ↗

Circulating tumor DNA moves further into the spotlightSemantic proximity Read ↗

Whole Cancer Genome Sequencing by Next-Generation MethodsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.