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Article

Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity

19 Sept 2018

Abstract excerpt

How tumor microenvironmental forces shape plasticity of cancer cell morphology is poorly understood. Here, we conduct automated histology image and spatial statistical analyses in 514 high grade serous ovarian samples to define cancer morphological diversification within the spatial context of the microenvironment. Tumor spatial zones, where cancer cell nuclei diversify in shape, are mapped in each tumor....

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PMID: 30254278
DOI: 10.1038/s41467-018-06130-3

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