Article

Nuclear Irregularity as a Universal Diagnostic Tool in Solid Tumors

2025-08-15

Abstract excerpt

As tumors develop, cancer cells accumulate diverse genomic and phenotypic alterations to meet heightened demands for energy production and biosynthesis. Loss of lamina function and perturbations in energy production are associated with pronounced aberrations in cellular morphology, particularly within nuclear architecture and the plasma membrane. Systematic analysis of nuclear morphology can reveal conserved struc...

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Literature Corpus work: 74ccf83b-838a-5445-8bd4-96e9bf91800a
DOI: 10.1101/2025.08.12.669986

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