Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma?: Lessons From the PAOLA-1/ENGOT-ov25 Trial, a GINECO Study.

doi:10.5858/arpa.2024-0081-OA

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Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma?: Lessons From the PAOLA-1/ENGOT-ov25 Trial, a GINECO Study.

Archives of pathology & laboratory medicine - 1 Aug 2025

Kime Amel, Bataillon Guillaume, Treilleux Isabelle, Callens Céline, Selle Frédéric, Heitz Florian, Cinieri Saverio, González-Martin Antonio, Schauer Christian, Lindahl Gabriel, Parma Gabriella, Vergote Ignace, Matsumoto Takashi, Blonz Cyriac, Canzler Ulrich, Mosconi Anna Maria, Guerra Alía Eva María, Pujade-Lauraine Eric, Genestie Catherine, Ray-Coquard Isabelle, Just Pierre-Alexandre

Abstract excerpt

CONTEXT.—: A correlation between the morphology of ovarian high-grade serous carcinomas (HGSOCs) and BRCA mutations has been previously reported. OBJECTIVE.—: To investigate, beyond BRCA, the association between the morphology of HGSOC and the presence of homologous recombination deficiency (HRD). DESIGN.—: We reviewed 522 of 806 cases of HGSOC from the PAOLA-1 clinical trial, including 163 cases with tumor BRCA...

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PMID: 39648143
DOI: 10.5858/arpa.2024-0081-OA

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Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma?: Lessons From the PAOLA-1/ENGOT-ov25 Trial, a GINECO Study.PMID 39648143Read ↗

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