Article

Convergent stromal and immune remodeling defines spatial tumor dynamics in PARP inhibitor–resistant high-grade serous ovarian cancer

2026-03-05

Abstract excerpt

Acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) remains a major barrier to durable clinical benefit in patients with high-grade serous ovarian cancer (HGSOC), yet the profiles of tumors at resistance remain poorly understood. We profiled longitudinal HGSOC patient tumors spanning diagnosis, post-neoadjuvant therapy, and progression on PARPi with complementary spatial transcriptomics platforms...

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Literature Corpus work: abc34374-3732-5f9f-8dc4-b6aca516759e
DOI: 10.64898/2026.03.03.709035

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