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Article

Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal Cancer.

Cancer discovery - 1 Mar 2023

Holowatyj Andreana N, Wen Wanqing, Gibbs Timothy, Seagle Hannah M, Keller Samantha R, Edwards Digna R Velez, Washington Mary K, Eng Cathy, Perea Jose, Zheng Wei, Guo Xingyi

Abstract excerpt

Molecular features underlying colorectal cancer disparities remain uncharacterized. Here, we investigated somatic mutation patterns by race/ethnicity and sex among 5,856 non-Hispanic white (NHW), 535 non-Hispanic Black (NHB), and 512 Asian/Pacific Islander (API) patients with colorectal cancer (2,016 early-onset colorectal cancer patients: sequencing age <50 years). NHB patients with early-onset nonhypermutated...

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Identifiers

PMID: 36520636
DOI: 10.1158/2159-8290.CD-22-0764
PMCID: PMC10436779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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