Article
The Genomics of Colorectal Cancer in Populations with African and European Ancestry.
Cancer discovery - 2 May 2022
Myer Parvathi A, Lee Jessica K, Madison Russell W, Pradhan Kith, Newberg Justin Y, Isasi Carmen R, Klempner Samuel J, Frampton Garrett M, Ross Jeffery S, Venstrom Jeffrey M, Schrock Alexa B, Das Sudipto, Augenlicht Leonard, Verma Amit, Greally John M, Raj Srilakshmi M, Goel Sanjay, Ali Siraj M
Abstract excerpt
Black people have a higher incidence of colorectal cancer and worse survival rates when compared with white people. Comprehensive genomic profiling was performed in 46,140 colorectal adenocarcinoma cases. Ancestry-informative markers identified 5,301 patients of African descent (AFR) and 33,770 patients of European descent (EUR). AFR were younger, had fewer microsatellite instability-high (MSI-H) tumors, and had...
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