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Article

Novel recurrently mutated genes in African American colon cancers.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2015

Guda Kishore, Veigl Martina L, Varadan Vinay, Nosrati Arman, Ravi Lakshmeswari, Lutterbaugh James, Beard Lydia, Willson James K V, Sedwick W David, Wang Zhenghe John, Molyneaux Neil, Miron Alexander, Adams Mark D, Elston Robert C, Markowitz Sanford D, Willis Joseph E

Abstract excerpt

We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations...

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Identifiers

PMID: 25583493
DOI: 10.1073/pnas.1417064112
PMCID: PMC4313860

Genes

EPHA6
FLCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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