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Article

Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer.

Human mutation - 1 Jul 2013

Smith Christopher G, Naven Marc, Harris Rebecca, Colley James, West Hannah, Li Ning, Liu Yuan, Adams Richard, Maughan Timothy S, Nichols Laura, Kaplan Richard, Wagner Michael J, McLeod Howard L, Cheadle Jeremy P

Abstract excerpt

Inherited factors account for around one third of all colorectal cancers (CRCs) and include rare high penetrance mutations in APC, MSH2, MSH6, and POLE. Here, we sought novel tumor-suppressor genes that predispose to CRC by exome resequencing 50 sporadic patients with advanced CRC (18 diagnosed ≤35 years of age) at a mean coverage of 30×. To help identify potentially pathogenic alleles, we initially sought rare...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

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Share to Poly-ADP-Ribose Binding Proteins

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Source

Identifiers

PMID: 23585368
DOI: 10.1002/humu.22333

Genes

APC
POLE
FANCM
LAMB4
LAMC3
MSH2
MSH6
NOTCH3
TREX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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