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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress

1 Sept 2018

Abstract excerpt

The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains unclear. We addressed this question by analyzing proteins associated with replication forks in cells with or without FANCJ. We demonstrate that FANCJ-knockout (FANCJ-KO) cells have alterations in the replisome that are consistent with...

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PMID: 30232006
DOI: 10.1016/j.celrep.2018.08.065

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