Article
FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.
Nucleic acids research - 20 Apr 2016
Rohleder Florian, Huang Jing, Xue Yutong, Kuper Jochen, Round Adam, Seidman Michael, Wang Weidong, Kisker Caroline
Abstract excerpt
FANCM is a highly conserved DNA remodeling enzyme that promotes the activation of the Fanconi anemia DNA repair pathway and facilitates replication traverse of DNA interstrand crosslinks. However, how FANCM interacts with the replication machinery to promote traverse remains unclear. Here, we show that FANCM and its archaeal homolog Hef from Thermoplasma acidophilum interact with proliferating cell nuclear...
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