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Article

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.

Nucleic acids research - 16 Nov 2017

Thompson Elizabeth L, Yeo Jung E, Lee Eun-A, Kan Yinan, Raghunandan Maya, Wiek Constanze, Hanenberg Helmut, Schärer Orlando D, Hendrickson Eric A, Sobeck Alexandra

Abstract excerpt

Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection on chromatin, the FA core complex monoubiquitinates and recruits the central FANCI and FANCD2 proteins that subsequently coordinate ICL removal and repair of the ensuing DNA...

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Share to Chromatin
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Fanconi Anemia Complementation Group Proteins

Share to HCT116 Cells

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Source

Open in PubMed Open full text

Identifiers

PMID: 29059323
DOI: 10.1093/nar/gkx847
PMCID: PMC5714191

Genes

FANCD2
FANCI
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.PMID 29059323Read ↗

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