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Article

FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery

8 May 2013

Abstract excerpt

Fanconi Anemia (FA) and Bloom Syndrome share overlapping phenotypes including spontaneous chromosomal abnormalities and increased cancer predisposition. The FA protein pathway comprises an upstream core complex that mediates recruitment of two central players, FANCD2 and FANCI, to sites of stalled replication forks. Successful fork recovery depends on the Bloom's helicase BLM that participates in a larger protein...

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PMID: 23658231
DOI: 10.1093/nar/gkt348

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FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recoveryPMID 23658231Read ↗

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