Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.

Mutation research - 31 Jul 2009

Thompson Larry H, Hinz John M

Abstract excerpt

The Fanconi anemia (FA) molecular network consists of 15 "FANC" proteins, of which 13 are associated with mutations in patients with this cancer-prone chromosome instability disorder. Whereas historically the common phenotype associated with FA mutations is marked sensitivity to DNA interstrand crosslinking agents, the literature supports a more global role for FANC proteins in coping with diverse stresses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Chromosomal Instability
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to DNA Replication

Share to Fanconi Anemia

Share to Fanconi Anemia Complementation Group Proteins

Share to Sister Chromatid Exchange

Source

Open in PubMed Open full text

Identifiers

PMID: 19622404
DOI: 10.1016/j.mrfmmm.2009.02.003
PMCID: PMC2714807

Genes

FANCD2
FANCI
FANCM
ATR
BACH1
BRCA1
BRCA2
BRIP1
FAAP24
FANCA
FANCL
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.PMID 19622404Read ↗

How Fanconi anemia proteins promote the four Rs: replication, recombination, repair, and recovery.Semantic proximity Read ↗

Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.Semantic proximity Read ↗

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.Semantic proximity Read ↗

Comprehensive review on Fanconi anemia: insights into DNA interstrand cross-links, repair pathways, and associated tumorsSemantic proximity Read ↗

The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-LinksSemantic proximity Read ↗

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.Semantic proximity Read ↗

Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy.Semantic proximity Read ↗

The Fanconi Anemia Pathway of Genomic MaintenanceSemantic proximity Read ↗

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.Semantic proximity Read ↗

DNA crosslinking damage and cancer - a tale of friend and foe.Semantic proximity Read ↗

Folate stress as a Contributing Factor to Fanconi AnemiaSemantic proximity Read ↗

Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.