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Article

SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.

Blood - 21 Jan 2021

Okamoto Yusuke, Abe Masako, Mu Anfeng, Tempaku Yasuko, Rogers Colette B, Mochizuki Ayako L, Katsuki Yoko, Kanemaki Masato T, Takaori-Kondo Akifumi, Sobeck Alexandra, Bielinsky Anja-Katrin, Takata Minoru

Abstract excerpt

Fanconi anemia (FA) is a hereditary disorder caused by mutations in any 1 of 22 FA genes. The disease is characterized by hypersensitivity to interstrand crosslink (ICL) inducers such as mitomycin C (MMC). In addition to promoting ICL repair, FA proteins such as RAD51, BRCA2, or FANCD2 protect stalled replication forks from nucleolytic degradation during replication stress, which may have a profound impact on FA...

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Identifiers

PMID: 32735670
DOI: 10.1182/blood.2019003782
PMCID: PMC7819757

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