Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.

Molecular and cellular biology - 1 Jun 2008

Wu Yuliang, Shin-ya Kazuo, Brosh Robert M

Abstract excerpt

FANCJ mutations are associated with breast cancer and genetically linked to the bone marrow disease Fanconi anemia (FA). The genomic instability of FA-J mutant cells suggests that FANCJ helicase functions in the replicational stress response. A putative helicase with sequence similarity to FANCJ in Caenorhabditis elegans (DOG-1) and mouse (RTEL) is required for poly(G) tract maintenance, suggesting its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic-Leucine Zipper Transcription Factors
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia

Share to Fanconi Anemia Complementation Group Proteins

Share to Genomic Instability

Share to Nucleic Acid Conformation

Share to Nucleic Acid Denaturation

Share to Replication Protein A

Source

Open in PubMed Open full text

Identifiers

PMID: 18426915
DOI: 10.1128/MCB.02210-07
PMCID: PMC2423121

Genes

MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.PMID 18426915Read ↗

Genomic stability: FANCJ-dependent G4 DNA repair.Semantic proximity Read ↗

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.Semantic proximity Read ↗

DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.Semantic proximity Read ↗

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during StressSemantic proximity Read ↗

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.Semantic proximity Read ↗

DNA repair helicases: from mechanistic understanding to therapeutic implications.Semantic proximity Read ↗

DNA helicases associated with genetic instability, cancer, and aging.Semantic proximity Read ↗

Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.Semantic proximity Read ↗

The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-LinksSemantic proximity Read ↗

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.Semantic proximity Read ↗

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.Semantic proximity Read ↗

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.