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Article

Systematic evaluation of signal-to-noise ratio in variant detection from single cell genome multiple displacement amplification and exome sequencing.

BMC genomics - 17 Sept 2018

Simonsen Anita T, Hansen Marcus C, Kjeldsen Eigil, Møller Peter L, Hindkjær Johnny J, Hokland Peter, Aggerholm Anni

Abstract excerpt

BACKGROUND: The current literature on single cell genomic analyses on the DNA level is conflicting regarding requirements for cell quality, amplification success rates, allelic dropouts and resolution, lacking a systematic comparison of multiple cell input down to the single cell. We hypothesized that such a correlation assay would provide an approach to address the latter issues, utilizing the leukemic cell line...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30223769
DOI: 10.1186/s12864-018-5063-5
PMCID: PMC6142419

Genes

DNMT3A
NPM1
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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