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scDPN for High-Throughput Single-Cell CNV Detection to Uncover Clonal Evolution During HCC Recurrence

1 Jun 2021

Abstract excerpt

Single-cell genomics provides substantial resources for dissecting cellular heterogeneity and cancer evolution. Unfortunately, classical DNA amplification-based methods have low throughput and introduce coverage bias during sample preamplification. We developed a single-cell DNA library preparation method without preamplification in nanolitre scale (scDPN) to address these issues. The method achieved a throughput...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34280548
DOI: 10.1016/j.gpb.2021.03.008

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