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Article

Microarray analysis of copy number variation in single cells.

Nature protocols - 19 Jan 2012

Konings Peter, Vanneste Evelyne, Jackmaert Sigrun, Ampe Michèle, Verbeke Geert, Moreau Yves, Vermeesch Joris Robert, Voet Thierry

Abstract excerpt

We present a protocol for reliably detecting DNA copy number aberrations in a single human cell. Multiple displacement-amplified DNAs of a cell are hybridized to a 3,000-bacterial artificial chromosome (BAC) array and to an Affymetrix 250,000 (250K)-SNP array. Subsequent copy number calling is based on the integration of BAC probe-specific copy number probabilities that are estimated by comparing probe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22262009
DOI: 10.1038/nprot.2011.426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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