Article
Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukemia.
Genes, chromosomes & cancer - 1 Jul 2016
Vosberg Sebastian, Herold Tobias, Hartmann Luise, Neumann Martin, Opatz Sabrina, Metzeler Klaus H, Schneider Stephanie, Graf Alexander, Krebs Stefan, Blum Helmut, Baldus Claudia D, Hiddemann Wolfgang, Spiekermann Karsten, Bohlander Stefan K, Mansmann Ulrich, Greif Philipp A
Abstract excerpt
High throughput sequencing approaches, including the analysis of exomes or gene panels, are widely used and established to detect tumor-specific sequence variants such as point mutations or small insertions/deletions. Beyond single nucleotide resolution, sequencing data also contain information on changes in sequence coverage between samples and thus allow the detection of somatic copy number alterations (CNAs)...
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