Article
Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring.
BMC medical genomics - 4 Mar 2020
Crowgey Erin L, Mahajan Nitin, Wong Wing Hing, Gopalakrishnapillai Anilkumar, Barwe Sonali P, Kolb E Anders, Druley Todd E
Abstract excerpt
BACKGROUND: Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smaller genomic alternations. Next-generation sequencing (NGS) assays are being increasingly utilized for assessment of these...
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