Article

A highly scalable method for joint whole genome sequencing and gene expression profiling of single cells

2020-03-05

Abstract excerpt

Understanding how genetic variation alters gene expression - how genotype affects phenotype - is a central challenge in biology. To address this question in complex cell mixtures, we developed Direct Nuclear Tagmentation and RNA-sequencing (DNTR-seq), which enables whole genome and mRNA sequencing jointly in single cells. When applied to biobanked leukemia samples, DNTR-seq readily identified minor subclones withi...

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Literature Corpus work: 49775ea1-3cc3-5a47-80a7-16df5f37babc
DOI: 10.1101/2020.03.04.976530

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