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Article

Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016

Leung Kaston, Klaus Anders, Lin Bill K, Laks Emma, Biele Justina, Lai Daniel, Bashashati Ali, Huang Yi-Fei, Aniba Radhouane, Moksa Michelle, Steif Adi, Mes-Masson Anne-Marie, Hirst Martin, Shah Sohrab P, Aparicio Samuel, Hansen Carl L

Abstract excerpt

The genomes of large numbers of single cells must be sequenced to further understanding of the biological significance of genomic heterogeneity in complex systems. Whole genome amplification (WGA) of single cells is generally the first step in such studies, but is prone to nonuniformity that can compromise genomic measurement accuracy. Despite recent advances, robust performance in high-throughput single-cell WGA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27412862
DOI: 10.1073/pnas.1520964113
PMCID: PMC4968760

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