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Article

Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow.

PloS one - 12 Dec 2007

Iwamoto Kazuya, Bundo Miki, Ueda Junko, Nakano Yoko, Ukai Wataru, Hashimoto Eri, Saito Toshikazu, Kato Tadafumi

Abstract excerpt

BACKGROUND: In single-cell human genome analysis using whole-genome amplified product, a strong amplification bias involving allele dropout and preferential amplification hampers the quality of results. Using an oligonucleotide single nucleotide polymorphism (SNP) array, we systematically examined the nature of this amplification bias, including frequency, degree, and preference for genomic location, and we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18074030
DOI: 10.1371/journal.pone.0001306
PMCID: PMC2111048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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