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Article

Structural Alterations in Human Fibroblast Growth Factor Receptors in Carcinogenesis.

Biochemistry. Biokhimiia - 1 Aug 2018

Mikhaylenko D S, Alekseev B Y, Zaletaev D V, Goncharova R I, Nemtsova M V

Abstract excerpt

Fibroblast growth factor (FGF) plays an important role in human embryogenesis, angiogenesis, cell proliferation, and differentiation. Carcinogenesis is accompanied by aberrant constitutive activation of FGF receptors (FGFRs) resulting from missense mutation in the FGFR1-4 genes, generation of chimeric oncogenes, FGFR1-4 gene amplification, alternative splicing shift toward formation of mesenchymal FGFR isoforms,...

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Source

Identifiers

PMID: 30208830
DOI: 10.1134/S0006297918080059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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