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Article

Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications.

Cancer metastasis reviews - 1 Sept 2015

Helsten Teresa, Schwaederle Maria, Kurzrock Razelle

Abstract excerpt

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival. FGFR germline mutations (activating) can cause skeletal disorders, primarily dwarfism (generally mutations in FGFR3), and craniofacial malformation syndromes (usually...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26224133
DOI: 10.1007/s10555-015-9579-8
PMCID: PMC4573649

Genes

FGFR1
FGFR2
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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