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Fibroblast growth factor receptor (FGFR) gene: pathogenesis and treatment implications in urothelial carcinoma of the bladder.

Journal of clinical pathology - 1 Aug 2021

Al-Obaidy Khaleel I, Cheng Liang

Abstract excerpt

Dysregulation of fibroblast growth factor receptors (FGFRs) has been implicated in several human malignancies, including urothelial carcinoma. In urothelial carcinoma, the oncogenic role of mutated FGFR is mediated by the RAS-mitogen-activated protein kinase pathway, resembling the effects observed with activated HRAS Activating somatic mutations of FGFR3 are clustered in three hotspots in exons 7, 10 and 15, and...

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Gene Fusion
Phenylurea Compounds
Pyrazoles
Pyrroles
Quinoxalines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Fibroblast Growth Factor, Type 3

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PMID: 33731335
DOI: 10.1136/jclinpath-2020-207115

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