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Article

FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention.

International journal of molecular sciences - 18 Sept 2020

De Luca Antonella, Esposito Abate Riziero, Rachiglio Anna Maria, Maiello Monica Rosaria, Esposito Claudia, Schettino Clorinda, Izzo Francesco, Nasti Guglielmo, Normanno Nicola

Abstract excerpt

Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors involved in many biological processes. Deregulated FGFR signaling plays an important role in tumor development and progression in different cancer types. FGFR genomic alterations, including FGFR gene fusions that originate by chromosomal rearrangements, represent a promising therapeutic target. Next-generation-sequencing (NGS) approaches...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32962091
DOI: 10.3390/ijms21186856
PMCID: PMC7555921

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